Bayesian hierarchical model-based network meta-analysis to overcome survival extrapolation challenges caused by data immaturity

• Main Authors: Bart Heeg (Author), Andre Verhoek (Author), Gabriel Tremblay (Author), Ofir Harari (Author), Mohsen Soltanifar (Author), Haitao Chu (Author), Satrajit Roychoudhury (Author), Joseph C Cappelleri (Author)
• Format: Book
• Published: Becaris Publishing Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: This research evaluated standard Weibull mixture cure (WMC) network meta-analysis (NMA) with Bayesian hierarchical (BH)WMCNMAto inform long-term survival of therapies. Materials & methods: Four trials in previously treated metastatic non-small-cell lung cancer with PD-L1 >1% were used co...