The taming of PARP1 and its impact on NAD+ metabolism

• Main Authors: Sarah Hurtado-Bagès (Author), Gunnar Knobloch (Author), Andreas G. Ladurner (Author), Marcus Buschbeck (Author)
• Formato: Livro
• Publicado em: Elsevier, 2020-08-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Background: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. Sco...