The taming of PARP1 and its impact on NAD+ metabolism
Background: Poly-ADP-ribose polymerases (PARPs) are key mediators of cellular stress response. They are intimately linked to cellular metabolism through the consumption of NAD+. PARP1/ARTD1 in the nucleus is the major NAD+ consuming activity and plays a key role in maintaining genomic integrity. Sco...
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Main Authors: | Sarah Hurtado-Bagès (Author), Gunnar Knobloch (Author), Andreas G. Ladurner (Author), Marcus Buschbeck (Author) |
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Format: | Book |
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Elsevier,
2020-08-01T00:00:00Z.
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