PLK1 protects intestinal barrier function during sepsis by targeting mitochondrial dynamics through TANK-NF-κB signalling

• Main Authors: Ying-Ya Cao (Author), Yuan Zhang (Author), Wuyun Gerile (Author), Yan Guo (Author), Li-Na Wu (Author), Li-Li Wu (Author), Kai Song (Author), Wei-Hua Lu (Author), Jian-Bo Yu (Author)
• Format: Book
• Published: BMC, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Intestinal barrier integrity in the pathogenesis of sepsis is critical. Despite an abundance of evidence, the molecular mechanism of the intestinal barrier in sepsis pathology remains unclear. Here, we report a protective role of polo-like kinase 1 (PLK1) in intestinal barrier in...