Hepatic c-Jun regulates glucose metabolism via FGF21 and modulates body temperature through the neural signals

• Main Authors: Fei Xiao (Author), Yajie Guo (Author), Jiali Deng (Author), Feixiang Yuan (Author), Yuzhong Xiao (Author), Lijian Hui (Author), Yu Li (Author), Zhimin Hu (Author), Yuncai Zhou (Author), Kai Li (Author), Xiao Han (Author), Qichen Fang (Author), Weiping Jia (Author), Yan Chen (Author), Hao Ying (Author), Qiwei Zhai (Author), Shanghai Chen (Author), Feifan Guo (Author)
• Format: Book
• Published: Elsevier, 2019-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: c-Jun, a prominent member of the activator protein 1 (AP-1) family, is involved in various physiology processes such as cell death and survival. However, a role of hepatic c-Jun in the whole-body metabolism is poorly understood. Methods: We generated liver-specific c-Jun knock-out (c-jun△...