Effect of cenobamate on the single‐dose pharmacokinetics of multiple cytochrome P450 probes using a cocktail approach in healthy subjects

• Autors principals: Stephen A. Greene (Autor), Charles Kwak (Autor), Marc Kamin (Autor), Laurent Vernillet (Autor), Kelli J. Glenn (Autor), Lana Gabriel (Autor), Hong Wook Kim (Autor)
• Format: Llibre
• Publicat: Wiley, 2022-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Abstract This study was designed to evaluate the effects of cenobamate, an antiseizure medication for focal seizures, on the pharmacokinetics of cytochrome P450 probes (bupropion, CYP2B6; midazolam, CYP3A4/5; warfarin, CYP2C9; and omeprazole, CYP2C19) in healthy subjects. Probes were administered al...