Notochordal-Cell-Derived Exosomes Induced by Compressive Load Inhibit Angiogenesis via the miR-140-5p/Wnt/β-Catenin Axis

• Main Authors: Zhen Sun (Author), Bing Liu (Author), Zhi-Heng Liu (Author), Wen Song (Author), Dong Wang (Author), Bei-Yu Chen (Author), Jing Fan (Author), Zhe Xu (Author), Dan Geng (Author), Zhuo-Jing Luo (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Angiogenesis is a pathological signature of intervertebral disc degeneration (IDD). Accumulating evidence has shown that notochordal cells (NCs) play an essential role in maintaining intervertebral disc development and homeostasis with inhibitive effect on blood vessel in-growth. However, the anti-a...