Suppression of Choroidal Neovascularization and Fibrosis by a Novel RNAi Therapeutic Agent against (Pro)renin Receptor

• Main Authors: Ye Liu (Author), Atsuhiro Kanda (Author), Di Wu (Author), Erdal Tan Ishizuka (Author), Satoru Kase (Author), Kousuke Noda (Author), Atsuhiro Ichihara (Author), Susumu Ishida (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The receptor-associated prorenin system refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates the tissue renin-angiotensin system (RAS) and RAS-independent signaling, and its activation contributes to the molecular pathogenesis of various ocular...