NTRK fusions in osteosarcoma are rare and non‐functional events

• Үндсэн зохиолчид: Baptiste Ameline (Зохиогч), Karim H Saba (Зохиогч), Michal Kovac (Зохиогч), Linda Magnusson (Зохиогч), Olaf Witt (Зохиогч), Stefan Bielack (Зохиогч), Michaela Nathrath (Зохиогч), Karolin H Nord (Зохиогч), Daniel Baumhoer (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Wiley, 2020-04-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Abstract Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a...