NTRK fusions in osteosarcoma are rare and non‐functional events

• Main Authors: Baptiste Ameline (Author), Karim H Saba (Author), Michal Kovac (Author), Linda Magnusson (Author), Olaf Witt (Author), Stefan Bielack (Author), Michaela Nathrath (Author), Karolin H Nord (Author), Daniel Baumhoer (Author)
• Format: Book
• Published: Wiley, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a...