Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing

• Main Authors: Efthymios Neroutsos (Author), Ricardo Nalda-Molina (Author), Anna Paisiou (Author), Kalliopi Zisaki (Author), Evgenios Goussetis (Author), Alexandros Spyridonidis (Author), Vasiliki Kitra (Author), Stelios Grafakos (Author), Georgia Valsami (Author), Aristides Dokoumetzidis (Author)
• Format: Book
• Published: MDPI AG, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We develop a population pharmacokinetic model to describe Busulfan pharmacokinetics in paediatric patients and investigate by simulations the impact of various sampling schedules on the calculation of AUC. Seventy-six children had 2 h infusions every 6 h. A two-compartment linear model was found to...