Development of a Population Pharmacokinetic Model of Busulfan in Children and Evaluation of Different Sampling Schedules for Precision Dosing

• Hauptverfasser: Efthymios Neroutsos (Verfasst von), Ricardo Nalda-Molina (Verfasst von), Anna Paisiou (Verfasst von), Kalliopi Zisaki (Verfasst von), Evgenios Goussetis (Verfasst von), Alexandros Spyridonidis (Verfasst von), Vasiliki Kitra (Verfasst von), Stelios Grafakos (Verfasst von), Georgia Valsami (Verfasst von), Aristides Dokoumetzidis (Verfasst von)
• Format: Buch
• Veröffentlicht: MDPI AG, 2022-03-01T00:00:00Z.
• Schlagworte: article
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We develop a population pharmacokinetic model to describe Busulfan pharmacokinetics in paediatric patients and investigate by simulations the impact of various sampling schedules on the calculation of AUC. Seventy-six children had 2 h infusions every 6 h. A two-compartment linear model was found to...