Improved Bioavailability and High Photostability of Methotrexate by Spray-Dried Surface-Attached Solid Dispersion with an Aqueous Medium

• Main Authors: Bhupendra Raj Giri (Author), Jung Suk Kim (Author), Jong Hyuck Park (Author), Sung Giu Jin (Author), Kyeong Soo Kim (Author), Fakhar ud Din (Author), Han Gon Choi (Author), Dong Wuk Kim (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Low aqueous solubility and poor bioavailability are major concerns in the development of oral solid-dosage drug forms. In this study, we fabricated surface-attached solid dispersion (SASD) to enhance the solubility, bioavailability, and photostability of methotrexate (MTX), a highly lipophilic and p...