Fc galactosylation follows consecutive reaction kinetics and enhances immunoglobulin G hexamerization for complement activation

• Main Authors: Bingchuan Wei (Author), Xuan Gao (Author), Lance Cadang (Author), Saeed Izadi (Author), Peilu Liu (Author), Hui-Min Zhang (Author), Elizabeth Hecht (Author), Jeongsup Shim (Author), Gordon Magill (Author), Juan Rincon Pabon (Author), Lu Dai (Author), Wilson Phung (Author), Elaine Lin (Author), Christopher Wang (Author), Kevin Whang (Author), Sean Sanchez (Author), Jose Oropeza Jr (Author), Julien Camperi (Author), Jennifer Zhang (Author), Wendy Sandoval (Author), Yonghua Taylor Zhang (Author), Guoying Jiang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fc galactosylation is a critical quality attribute for anti-tumor recombinant immunoglobulin G (IgG)-based monoclonal antibody (mAb) therapeutics with complement-dependent cytotoxicity (CDC) as the mechanism of action. Although the correlation between galactosylation and CDC has been known, the unde...