Rapamycin Upregulates Connective Tissue Growth Factor Expression in Hepatic Progenitor Cells Through TGF-β-Smad2 Dependent Signaling

• Main Authors: Yu Wu (Author), Wei Wang (Author), Xiang-mei Peng (Author), Yi He (Author), Yi-xiao Xiong (Author), Hui-fang Liang (Author), Liang Chu (Author), Bi-xiang Zhang (Author), Ze-yang Ding (Author), Xiao-ping Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rapamycin (sirolimus) is a mTOR kinase inhibitor and is widely used as an immunosuppressive drug to prevent graft rejection in organ transplantation currently. However, some recent investigations have reported that it had profibrotic effect in the progression of organ fibrosis, and its precise role...