An integrative approach of digital image analysis and transcriptome profiling to explore potential predictive biomarkers for TGFβ blockade therapy

• Main Authors: Robert Pomponio (Author), Qi Tang (Author), Anthony Mei (Author), Anne Caron (Author), Bema Coulibaly (Author), Joachim Theilhaber (Author), Maximilian Rogers-Grazado (Author), Michele Sanicola-Nadel (Author), Souad Naimi (Author), Reza Olfati-Saber (Author), Cecile Combeau (Author), Jack Pollard (Author), Tun Tun Lin (Author), Rui Wang (Author)
• Format: Book
• Published: Elsevier, 2022-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Increasing evidence suggests that the presence and spatial localization and distribution pattern of tumor infiltrating lymphocytes (TILs) is associate with response to immunotherapies. Recent studies have identified TGFβ activity and signaling as a determinant of T cell exclusion in the tumor microe...