The impact of glutathione S-transferase genotype and phenotype on the adverse drug reactions to azathioprine in patients with inflammatory bowel diseases

• Main Authors: Hui Liu (Author), Liang Ding (Author), Fangbin Zhang (Author), Yu Zhang (Author), Xiang Gao (Author), Pinjin Hu (Author), Huichang Bi (Author), Min Huang (Author)
• Format: Book
• Published: Elsevier, 2015-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Azathioprine (AZA) is a thiopurine prodrug which is widely used in patients with inflammatory bowel disease (IBD). However, the use is limited in one-third of patients because of adverse drug reactions (ADRs) or a lack of clinical response. It has been considered that the polymorphic enzyme thiopuri...