Gomisin M2 Inhibits Mast Cell-Mediated Allergic Inflammation via Attenuation of FcεRI-Mediated Lyn and Fyn Activation and Intracellular Calcium Levels

• Main Authors: Hima Dhakal (Author), Soyoung Lee (Author), Eun-Nam Kim (Author), Jin Kyeong Choi (Author), Min-Jong Kim (Author), Jinjoo Kang (Author), Young-Ae Choi (Author), Moon-Chang Baek (Author), Byungheon Lee (Author), Hyun-Shik Lee (Author), Tae-Yong Shin (Author), Gil-Saeng Jeong (Author), Sang-Hyun Kim (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mast cells are effector cells that induce allergic inflammation by secreting inflammatory mediators. Gomisin M2 (G.M2) is a lignan isolated from Schisandra chinensis (Turcz). Baill. exhibiting anti-cancer activities. We aimed to investigate the anti-allergic effects and the underlying mechanism of G...