Inhibition of TLR4/MAPKs Pathway Contributes to the Protection of Salvianolic Acid A Against Lipotoxicity-Induced Myocardial Damage in Cardiomyocytes and Obese Mice

• Main Authors: Zhen Yang (Author), Yanli Chen (Author), Zhaoyuan Yan (Author), Tian Tian Xu (Author), Xiangyao Wu (Author), Aiwen Pi (Author), Qingsheng Liu (Author), Hui Chai (Author), Songtao Li (Author), Xiaobing Dou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The occurrence of lipotoxicity during obesity-associated cardiomyopathy is detrimental to health. Salvianolic acid A (SAA), a natural polyphenol extract of Salvia miltiorrhiza Bunge (Danshen in China), is known to be cardioprotective. However, its clinical benefits against obesity-associated cardiom...