Using an animal model to predict the effective human dose for oral multiple sclerosis drugs

• Main Authors: Wei Liu (Author), Zhiheng Yu (Author), Ziyu Wang (Author), Emmanuelle L. Waubant (Author), Suodi Zhai (Author), Leslie Z. Benet (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The objective of this study was to determine the potential usefulness of an animal model to predict the appropriate dose of newly developed drugs for treating relapsing remitting multiple sclerosis (RRMS). Conversion of the lowest effective dose (LEffD) for mice and rats in the experimental...