High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS

• Main Authors: Minsong Guo (Author), Fengdan Zhu (Author), Wenqiao Qiu (Author), Gan Qiao (Author), Betty Yuen-Kwan Law (Author), Lu Yu (Author), Jianming Wu (Author), Yong Tang (Author), Chonglin Yu (Author), Dalian Qin (Author), Xiaogang Zhou (Author), Anguo Wu (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Discovery of drugs rapidly and effectively is an important aspect for Alzheimer's disease (AD). In this study, a novel high-throughput screening (HTS) method aims at screening the small-molecules with amyloid-β (Aβ) binding affinity from natural medicines, based on the combinational use of biol...