High-throughput screening for amyloid-β binding natural small-molecules based on the combinational use of biolayer interferometry and UHPLC−DAD-Q/TOF-MS/MS

• Autores principales: Minsong Guo (Autor), Fengdan Zhu (Autor), Wenqiao Qiu (Autor), Gan Qiao (Autor), Betty Yuen-Kwan Law (Autor), Lu Yu (Autor), Jianming Wu (Autor), Yong Tang (Autor), Chonglin Yu (Autor), Dalian Qin (Autor), Xiaogang Zhou (Autor), Anguo Wu (Autor)
• Formato: Libro
• Publicado: Elsevier, 2022-04-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Discovery of drugs rapidly and effectively is an important aspect for Alzheimer's disease (AD). In this study, a novel high-throughput screening (HTS) method aims at screening the small-molecules with amyloid-β (Aβ) binding affinity from natural medicines, based on the combinational use of biol...