A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism

• Main Authors: ffolliott M. Fisher (Author), MiSung Kim (Author), Ludivine Doridot (Author), Jeremy C. Cunniff (Author), Thomas S. Parker (Author), Daniel M. Levine (Author), Marc K. Hellerstein (Author), Lisa C. Hudgins (Author), Eleftheria Maratos-Flier (Author), Mark A. Herman (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Increased fructose consumption is a contributor to the burgeoning epidemic of non-alcoholic fatty liver disease (NAFLD). Recent evidence indicates that the metabolic hormone FGF21 is regulated by fructose consumption in humans and rodents and may play a functional role in this nutritional...