Ligand-based design, synthesis, computational insights, and in vitro studies of novel N-(5-Nitrothiazol-2-yl)-carboxamido derivatives as potent inhibitors of SARS-CoV-2 main protease

• Main Authors: Mohamed Elagawany (Author), Ayman Abo Elmaaty (Author), Ahmed Mostafa (Author), Noura M. Abo Shama (Author), Eman Y. Santali (Author), Bahaa Elgendy (Author), Ahmed A. Al-Karmalawy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The global outbreak of the COVID-19 pandemic provokes scientists to make a prompt development of new effective therapeutic interventions for the battle against SARS-CoV-2. A new series of N-(5-nitrothiazol-2-yl)-carboxamido derivatives were designed and synthesised based on the structural optimisati...