Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)

• Main Authors: Elias C. Padilha (Author), Jianyao Wang (Author), Ed Kerns (Author), Arthur Lee (Author), Wenwei Huang (Author), Jian-kang Jiang (Author), John McKew (Author), Abdul Mutlib (Author), Rosangela G. Peccinini (Author), Paul B. Yu (Author), Philip Sanderson (Author), Xin Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently no approved treatment exists for fibrodysplasia ossificans progressiva (FOP) patients, and disease progression results in severe restriction of joint function and premature mortality. LDN-193189 has been demonstrated to be efficacious in a mouse FOP disease model after oral administration....