Concomitant Administration of Capecitabine and Folate Supplements: Need to Encourage Medication Reconciliation

• Main Authors: Berenice Stefanelli (Author), Carmine Sellitto (Author), Emanuela De Bellis (Author), Martina Torsiello (Author), Nicola Bertini (Author), Angelo Maria Pezzullo (Author), Graziamaria Corbi (Author), Francesco Sabbatino (Author), Stefano Pepe (Author), Angela Tesse (Author), Valeria Conti (Author), Amelia Filippelli (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hand-Foot syndrome (HFS) and diarrhoea are dose-limiting Adverse Drug Reactions (ADRs) of capecitabine-based chemotherapy. Four polymorphisms in the <i>dihydropyrimidine dehydrogenase</i> (<i>DPYD</i>) gene, encoding the DPD enzyme responsible for the metabolism of fluoropyri...