PACAP and VIP inhibit the invasiveness of glioblastoma cells exposed to hypoxia through the regulation of HIFs and EGFR expression

• Main Authors: Grazia eMaugeri (Author), Agata Grazia eD'Amico (Author), Rita eReitano (Author), Gaetano eMagro (Author), Sebastiano eCavallaro (Author), Salvatore eSalomone (Author), Velia eD'Agata (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pituitary adenylate cyclase-activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) through the binding of vasoactive intestinal peptide receptors (VIPRs), perform a wide variety of effects in human cancers, including glioblastoma multiforme (GBM). This tumor is characterized by exten...