NCS 613, a Potent PDE4 Inhibitor, Displays Anti-Inflammatory and Anti-Proliferative Properties on A549 Lung Epithelial Cells and Human Lung Adenocarcinoma Explants

• Main Authors: Issaka Yougbare (Author), Lazare Belemnaba (Author), Caroline Morin (Author), Abdurazzag Abusnina (Author), Yannick F. Senouvo (Author), Thérèse Keravis (Author), Claire Lugnier (Author), Eric Rousseau (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic inflammation is a deleterious process occurring in several pulmonary diseases; it is a driving force promoting tumorigenesis. By regulating local cyclic nucleotide concentration, cyclic nucleotide phosphodiesterases (PDE) govern important biological processes, including inflammation and prol...