Discovery of Novel Inhibitors against ALS-Related SOD1(A4V) Aggregation through the Screening of a Chemical Library Using Differential Scanning Fluorimetry (DSF)

• Main Authors: Maria Giannakou (Author), Ifigeneia Akrani (Author), Angeliki Tsoka (Author), Vassilios Myrianthopoulos (Author), Emmanuel Mikros (Author), Constantinos Vorgias (Author), Dimitris G. Hatzinikolaou (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Cu/Zn Superoxide Dismutase 1 (SOD1) is a 32 kDa cytosolic dimeric metalloenzyme that neutralizes superoxide anions into oxygen and hydrogen peroxide. Mutations in SOD1 are associated with ALS, a disease causing motor neuron atrophy and subsequent mortality. These mutations exert their ha...