Discovery of Novel Inhibitors against ALS-Related SOD1(A4V) Aggregation through the Screening of a Chemical Library Using Differential Scanning Fluorimetry (DSF)

• Asıl Yazarlar: Maria Giannakou (Yazar), Ifigeneia Akrani (Yazar), Angeliki Tsoka (Yazar), Vassilios Myrianthopoulos (Yazar), Emmanuel Mikros (Yazar), Constantinos Vorgias (Yazar), Dimitris G. Hatzinikolaou (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2024-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Background: Cu/Zn Superoxide Dismutase 1 (SOD1) is a 32 kDa cytosolic dimeric metalloenzyme that neutralizes superoxide anions into oxygen and hydrogen peroxide. Mutations in SOD1 are associated with ALS, a disease causing motor neuron atrophy and subsequent mortality. These mutations exert their ha...