An 8-Hydroxy-Quinoline Derivative Protects Against Lipopolysaccharide-Induced Lethality in Endotoxemia by Inhibiting HMGB1-Mediated Caspase-11 Signaling

• Váldodahkkit: Xiangyu Wang (Dahkki), Jian Shi (Dahkki), Zhaozheng Li (Dahkki), Ling Li (Dahkki), Rui Zhang (Dahkki), Yang Bai (Dahkki), Junmei Li (Dahkki), Fang Liang (Dahkki), Yiting Tang (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Frontiers Media S.A., 2021-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Sepsis, an inflammatory syndrome secondary to infection, is the leading cause of in-hospital lethality. It is evidenced that LPS, the major pathological component of the Gram-negative bacteria membrane, predominantly contributes to the pathogenesis of sepsis. Cytoplasmic lipopolysaccharide (LPS) can...