SIRT6 polymorphism rs117385980 is associated with longevity and healthy aging in Finnish men

• मुख्य लेखकों: Katariina Hirvonen (लेखक), Hannele Laivuori (लेखक), Jari Lahti (लेखक), Timo Strandberg (लेखक), Johan G. Eriksson (लेखक), Peter Hackman (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: BMC, 2017-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Abstract Background Sirtuin-6 (SIRT6) is involved in various crucial cellular pathways, being a key regulator of telomere structure, DNA repair, metabolism, transcriptional control and the NF-kappa B pathway. Sirt6 knock-out mice have been reported to develop typical features of aging and senescence...