Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases

• Main Authors: Mike Petrassi (Author), Rob Barber (Author), Celine Be (Author), Sarah Beach (Author), Brian Cox (Author), Anne-Marie D'Souza (Author), Nick Duggan (Author), Martin Hussey (Author), Roy Fox (Author), Peter Hunt (Author), Gabor Jarai (Author), Takatoshi Kosaka (Author), Paul Oakley (Author), Viral Patel (Author), Neil Press (Author), David Rowlands (Author), Clemens Scheufler (Author), Oliver Schmidt (Author), Honnappa Srinivas (Author), Mary Turner (Author), Rob Turner (Author), John Westwick (Author), Alison Wolfreys (Author), Nuzhat Pathan (Author), Simon Watson (Author), Matthew Thomas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary arterial hypertension (PAH) has demonstrated multi-serotonin receptor dependent pathologies, characterized by increased tone (5-HT1B receptor) and complex lesions (SERT, 5-HT1B, 5-HT2B receptors) of the pulmonary vasculature together with right ventricular hypertrophy, ischemia and fibrosi...