Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability

• Hlavní autoři: Erin Seonaid Campbell (Autor), Hannah Batchelor (Autor), James Matthew Butler (Autor), Ibrahim Khadra (Autor), Nena Minstry (Autor), Konstantinos Stamatopoulos (Autor)
• Médium: Kniha
• Vydáno: University of Huddersfield Press, 2023-12-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically relevant model. Existing work using biorelevant...