Compatibility of Caco-2 cells with Simulated Intestinal Fluid-Predicting Permeability

• Main Authors: Erin Seonaid Campbell (Author), Hannah Batchelor (Author), James Matthew Butler (Author), Ibrahim Khadra (Author), Nena Minstry (Author), Konstantinos Stamatopoulos (Author)
• Format: Book
• Published: University of Huddersfield Press, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The Caco-2 cell model is considered the gold standard when analysing drug permeability and risk-assessing bioavailability. The use of Simulated Intestinal Fluid (SIF) as a tool in the Caco-2 models is beneficial as this generates a more physiologically relevant model. Existing work using biorelevant...