Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma

• Main Authors: Piao Luo (Author), Qian Zhang (Author), Shuo Shen (Author), Yehai An (Author), Lixia Yuan (Author), Yin-Kwan Wong (Author), Sizhe Huang (Author), Shaohui Huang (Author), Jingnan Huang (Author), Guangqing Cheng (Author), Jiahang Tian (Author), Yu Chen (Author), Xiaoyong Zhang (Author), Weiguang Li (Author), Songqi He (Author), Jigang Wang (Author), Qingfeng Du (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hepatocellular carcinoma (HCC) is one of most common and deadliest malignancies. Celastrol (Cel), a natural product derived from the Tripterygium wilfordii plant, has been extensively researched for its potential effectiveness in fighting cancer. However, its clinical application has been hindered b...