DTMP-prime: A deep transformer-based model for predicting prime editing efficiency and PegRNA activity

• Κύριοι συγγραφείς: Roghayyeh Alipanahi (Συγγραφέας), Leila Safari (Συγγραφέας), Alireza Khanteymoori (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Elsevier, 2024-12-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Prime editors are CRISPR-based genome engineering tools with significant potential for rectifying patient mutations. However, their usage requires experimental optimization of the prime editing guide RNA (PegRNA) to achieve high editing efficiency. This paper introduces the deep transformer-based mo...