Perindopril Improves Cardiac Function by Enhancing the Expression of SIRT3 and PGC-1α in a Rat Model of Isoproterenol-Induced Cardiomyopathy

• Автори: Zhenyu Zhu (Автор), Huihui Li (Автор), Wanli Chen (Автор), Yameng Cui (Автор), Anan Huang (Автор), Xin Qi (Автор)
• Формат: Книга
• Опубліковано: Frontiers Media S.A., 2020-02-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Mitochondrial biosynthesis regulated by the PGC-1α-NRF1-TFAM pathway is considered a novel potential therapeutic target to treat heart failure (HF). Perindopril (PER) is an angiotensin-converting enzyme inhibitor that has proven efficacy in the prevention of HF; however, its mechanism is not well es...