PPARδ Activation Mitigates 6-OHDA-Induced Neuronal Damage by Regulating Intracellular Iron Levels

• Main Authors: Won Jin Lee (Author), Hyuk Gyoon Lee (Author), Jinwoo Hur (Author), Gyeong Hee Lee (Author), Jun Pil Won (Author), Eunsu Kim (Author), Jung Seok Hwang (Author), Han Geuk Seo (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Intracellular iron accumulation in dopaminergic neurons contributes to neuronal cell death in progressive neurodegenerative disorders such as Parkinson's disease. However, the mechanisms of iron homeostasis in this context remain incompletely understood. In the present study, we assessed the ro...