A randomized, controlled Phase 1b trial of the Sm-TSP-2 Vaccine for intestinal schistosomiasis in healthy Brazilian adults living in an endemic area.

• Main Authors: David J Diemert (Author), Rodrigo Correa-Oliveira (Author), Carlo Geraldo Fraga (Author), Frederico Talles (Author), Marcella Rezende Silva (Author), Shital M Patel (Author), Shirley Galbiati (Author), Jessie K Kennedy (Author), Jordan S Lundeen (Author), Maria Flavia Gazzinelli (Author), Guangzhao Li (Author), Lara Hoeweler (Author), Gregory A Deye (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Hana M El Sahly (Author), Wendy A Keitel (Author), Jeffrey Bethony (Author), Robert L Atmar (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>Recombinant Schistosoma mansoni Tetraspanin-2 formulated on Alhydrogel (Sm-TSP-2/Alhydrogel) is being developed to prevent intestinal and hepatic disease caused by S. mansoni. The tegumentary Sm-TSP-2 antigen was selected based on its unique recognition by cytophilic a...