Beta cell identity changes with mild hyperglycemia: Implications for function, growth, and vulnerability

• Main Authors: Aref G. Ebrahimi (Author), Jennifer Hollister-Lock (Author), Brooke A. Sullivan (Author), Ryohei Tsuchida (Author), Susan Bonner-Weir (Author), Gordon C. Weir (Author)
• Format: Book
• Published: Elsevier, 2020-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: As diabetes develops, marked reductions of insulin secretion are associated with very modest elevations of glucose. We wondered if these glucose changes disrupt beta cell differentiation enough to account for the altered function. Methods: Rats were subjected to 90% partial pancreatectomi...