Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

• Prif Awduron: Yitian Zhou (Awdur), Kohei Fujikura (Awdur), Souren Mkrtchian (Awdur), Volker M. Lauschke (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Up to half of all patients do not respond to pharmacological treatment as intended. A substantial fraction of these inter-individual differences is due to heritable factors and a growing number of associations between genetic variations and drug response phenotypes have been identified. Importantly,...