Computational Methods for the Pharmacogenetic Interpretation of Next Generation Sequencing Data

• Main Authors: Yitian Zhou (Author), Kohei Fujikura (Author), Souren Mkrtchian (Author), Volker M. Lauschke (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Up to half of all patients do not respond to pharmacological treatment as intended. A substantial fraction of these inter-individual differences is due to heritable factors and a growing number of associations between genetic variations and drug response phenotypes have been identified. Importantly,...