Multi-Oxidant Environment as a Suicidal Inhibitor of Myeloperoxidase

• Egile Nagusiak: Ramona Clemen (Egilea), Lara Minkus (Egilea), Debora Singer (Egilea), Paul Schulan (Egilea), Thomas von Woedtke (Egilea), Kristian Wende (Egilea), Sander Bekeschus (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Tissue inflammation drives the infiltration of innate immune cells that generate reactive species to kill bacteria and recruit adaptive immune cells. Neutrophil activation fosters the release of myeloperoxidase (MPO) enzyme, a heme-containing protein generating hypochlorous acid (HOCl) from hydrogen...