Identification of a Difluorinated Alkoxy Sulfonyl Chloride as a Novel Antitumor Agent for Hepatocellular Carcinoma through Activating Fumarate Hydratase Activity

• Main Authors: Jin Jin (Author), Xujun Liang (Author), Wu Bi (Author), Ruijie Liu (Author), Sai Zhang (Author), Yi He (Author), Qingming Xie (Author), Shilei Liu (Author), Ji-Chang Xiao (Author), Pengfei Zhang (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fenofibrate is known as a lipid-lowering drug. Although previous studies have reported that fenofibrate exhibits potential antitumor activities, IC₅₀ values of fenofibrate could be as high as 200 μM. Therefore, we investigated the antitumor activities of six synthesized fenofi...