Identification of a Difluorinated Alkoxy Sulfonyl Chloride as a Novel Antitumor Agent for Hepatocellular Carcinoma through Activating Fumarate Hydratase Activity

• Auteurs principaux: Jin Jin (Auteur), Xujun Liang (Auteur), Wu Bi (Auteur), Ruijie Liu (Auteur), Sai Zhang (Auteur), Yi He (Auteur), Qingming Xie (Auteur), Shilei Liu (Auteur), Ji-Chang Xiao (Auteur), Pengfei Zhang (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Fenofibrate is known as a lipid-lowering drug. Although previous studies have reported that fenofibrate exhibits potential antitumor activities, IC₅₀ values of fenofibrate could be as high as 200 μM. Therefore, we investigated the antitumor activities of six synthesized fenofi...