Structural modeling of ion channels using AlphaFold2, RoseTTAFold2, and ESMFold

• Main Authors: Phuong Tran Nguyen (Author), Brandon John Harris (Author), Diego Lopez Mateos (Author), Adriana Hernández González (Author), Adam Michael Murray (Author), Vladimir Yarov-Yarovoy (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTIon channels play key roles in human physiology and are important targets in drug discovery. The atomic-scale structures of ion channels provide invaluable insights into a fundamental understanding of the molecular mechanisms of channel gating and modulation. Recent breakthroughs in deep lea...