Antihyperuricemic effect of mangiferin aglycon derivative J99745 by inhibiting xanthine oxidase activity and urate transporter 1 expression in mice

• Main Authors: Zhizhen Qin (Author), Shoubao Wang (Author), Yihuang Lin (Author), Ying Zhao (Author), Shengqian Yang (Author), Junke Song (Author), Tao Xie (Author), Jinlong Tian (Author), Song Wu (Author), Guanhua Du (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A mangiferin aglycon derivative J99745 has been identified as a potent xanthine oxidase (XOD) inhibitor by previous in vitro study. This study aimed to evaluate the hypouricemic effects of J99745 in experimental hyperuricemia mice, and explore the underlying mechanisms. Mice were orally administered...