Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma

• Main Authors: Hong Kyu Lee (Author), Mi Jung Kwon (Author), Yong Joon Ra (Author), Hee Sung Lee (Author), Hyoung Soo Kim (Author), Eun Sook Nam (Author), Seong Jin Cho (Author), Hye-Rim Park (Author), Soo Kee Min (Author), Jinwon Seo (Author), Ji-Young Choe (Author), Kyueng-Whan Min (Author), So Young Kang (Author)
• Format: Book
• Published: BMC, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target. PIK3CA, KRAS, an...