Design and Optimization of Pioglitazone Hydrochloride Self-Nanoemulsifying Drug Delivery System (SNEDDS) Incorporated into an Orally Disintegrating Tablet

• Autores principales: Mahmoud Teaima (Autor), Sandra Hababeh (Autor), Mai Khanfar (Autor), Fares Alanazi (Autor), Doaa Alshora (Autor), Mohammed El-Nabarawi (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2022-02-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Pioglitazone Hydrochloride (PGZ) suffers from poor aqueous solubility. The aim of this research was to design orally disintegrating tablets with self-nanoemulsifying properties (T-SNEDDS) to improve the Pioglitazone solubility and dissolution rate. Three liquid self-nanoemulsifying systems (L-SNEDDS...