A computational method for immune repertoire mining that identifies novel binders from different clonotypes, demonstrated by identifying anti-pertussis toxoid antibodies

• Main Authors: Eve Richardson (Author), Jacob D. Galson (Author), Paul Kellam (Author), Dominic F. Kelly (Author), Sarah E. Smith (Author), Anne Palser (Author), Simon Watson (Author), Charlotte M. Deane (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Due to their shared genetic history, antibodies from the same clonotype often bind to the same epitope. This knowledge is used in immune repertoire mining, where known binders are used to search bulk sequencing repertoires to identify new binders. However, current computational methods cannot identi...