Coptisine-induced inhibition of Helicobacter pylori: elucidation of specific mechanisms by probing urease active site and its maturation process

• Main Authors: Cailan Li (Author), Ping Huang (Author), Kambo Wong (Author), Yifei Xu (Author), Lihua Tan (Author), Hanbin Chen (Author), Qiang Lu (Author), Chaodan Luo (Author), Chunlai Tam (Author), Lixiang Zhu (Author), Ziren Su (Author), Jianhui Xie (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In this study, we examined the anti-Helicobactor pylori effects of the main protoberberine-type alkaloids in Rhizoma Coptidis. Coptisine exerted varying antibacterial and bactericidal effects against three standard H. pylori strains and eleven clinical isolates, including four drug-resistant strains...