Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells

• Main Authors: Olaf Sommerburg (Author), Tilman Grune (Author), Sabine Klee (Author), Fritz R. Ungemach (Author), Werner G. Siems (Author)
• Format: Book
• Published: Hindawi Limited, 1993-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bromotrichloromethane (CBrCl3) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl4 treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory pro...