Anti-Caries Effect of a Mouthwash Containing <i>Sambucus williamsii var. coreana</i> Extract: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
This study was performed to verify the clinical effect of a mouthwash containing <i>Sambucus williamsii var. coreana</i> extract on the acid production of oral bacteria and bacteria involved in dental caries. A randomized, double-blind, and placebo-controlled trial was conducted on 66 pa...
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| Format: | Book |
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MDPI AG,
2022-04-01T00:00:00Z.
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| Summary: | This study was performed to verify the clinical effect of a mouthwash containing <i>Sambucus williamsii var. coreana</i> extract on the acid production of oral bacteria and bacteria involved in dental caries. A randomized, double-blind, and placebo-controlled trial was conducted on 66 patients of the following groups: a <i>Sambucus williamsii var. coreana</i> extract gargle group (<i>n</i> = 34) and a saline solution gargle group (<i>n</i> = 32). According to the application time of a mouthwash (before gargle application, immediately after gargle application, and five days after gargle application), we examined the emergence of dental caries-causing bacteria by PCR analysis and changes in the amount of acid production in dental plaque through a Cariview test. As a result of verifying the effect of inhibiting and preventing dental caries in the oral environment, the dental caries-causing bacteria decreased in the <i>Sambucus williamsii var. coreana</i> extract gargle group compared to the saline gargle group. In particular, <i>Streptococcus mutans</i> showed a marked decrease from immediately after application of gargle to 5 days after application. In addition, the mouthwash containing <i>Sambucus williamsii var. coreana</i> extract did not cause acid production and had low dental caries activity. A mouthwash containing <i>Sambucus williamsii var. coreana</i> extract, a natural substance, can be used as an anti-dental caries agent and be commercialized as an effective dental caries prevention agent that is safe for teeth and has an excellent antibacterial effect. |
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| Item Description: | 10.3390/antibiotics11040488 2079-6382 |