Intact provirus and integration sites analysis in acute HIV-1 infection and changes after one year of early antiviral therapy

• Main Authors: Gabriella Rozera (Author), Giuseppe Sberna (Author), Giulia Berno (Author), Cesare Ernesto Maria Gruber (Author), Emanuela Giombini (Author), Pietro Giorgio Spezia (Author), Nicoletta Orchi (Author), Vincenzo Puro (Author), Annalisa Mondi (Author), Enrico Girardi (Author), Francesco Vaia (Author), Andrea Antinori (Author), Fabrizio Maggi (Author), Isabella Abbate (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and objectives: HIV-1 provirus integration in host genomes provides a lifelong reservoir of virally infected cells. Although not able to generate viral progeny, the expression of defective proviruses has been associated with activation. Provirus integration may influence host gene transcr...