Impact of microRNA polymorphisms on high-dose methotrexate-related hematological toxicities in pediatric acute lymphoblastic leukemia

• Main Authors: Min Zhan (Author), Ting Liu (Author), Zhou Zhang (Author), Guoqiang Wang (Author), Zhongqiang Cao (Author), Xuejuan Li (Author), Hongwu Zeng (Author), Huirong Mai (Author), Zebin Chen (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ObjectivesIt is well known that transporter and enzyme genes could be regulated by microRNA (miRNA) at the post-transcriptional level, and single-nucleotide polymorphisms (SNPs) in miRNA, which are involved in the miRNA production and structure, may impact the miRNA expression level and then influen...